Preoperative weight loss interventions before total hip and knee arthroplasty: a systematic review of randomized controlled trials

Table 2 GRADE summary of findings

Outcome	Absolute effect (95% CI)	Relative effect (95% CI)	Participants (studies)	Certainty of the evidence (GRADE)	Comments
Length of stay	Mean difference 0.4 day fewer (1.69 fewer to 0.89 more)	/	198 (3 RCTs)	⨁⨁⨁⨁ High	little to no difference in LOS between both groups.
Surgical outcome (complication free)	115 more per 1,000 (from 13 to 167 more)	OR 2.49 (1.08 to 5.74)	198 (3 RCTs)	⨁⨁◯◯ Low	Weight‐loss intervention may result in surgery without complications but the evidence is uncertain.
Weight change (kg)	Mean difference 10.19 kg lower (17.89 lower to 2.5 lower)	/	198 (3 RCTs)	⨁⨁⨁◯ Moderate	Moderate evidence suggested weight‐loss intervention may result in weight loss during study period.
BMI change	Mean difference 3.45 lower (6.39 lower to 0.5 lower)	/	198 (3 RCTs)	⨁⨁⨁◯ Moderate	Moderate evidence suggested weight‐loss intervention may reduce BMI during study period.

Certainty of the evidence (GRADE):
⨁⨁◯◯ = Low, confidence in the effect estimate is limited; the true effect may be substantially different from the estimate of the effect
⨁⨁⨁◯ = Moderate, moderately confident in the effect estimate, the true effect is likely to be close to the estimate of the effect but there is a possibility that it is substantially different
⨁⨁⨁⨁ = High, very confident that the true effect lies close to that of the estimate of the effect

ISSN: 2524-7948